Hydration Mimicry by Membrane Ion Channels.

  title={Hydration Mimicry by Membrane Ion Channels.},
  author={Mangesh I Chaudhari and Juan M. Vanegas and Lawrence R Pratt and Ajay Muralidharan and Susan L B Rempe},
  journal={Annual review of physical chemistry},
Ions transiting biomembranes might pass readily from water through ion-specific membrane proteins if these protein channels provide environments similar to the aqueous solution hydration environment. Indeed, bulk aqueous solution is an important reference condition for the ion permeation process. Assessment of this hydration mimicry concept depends on understanding the hydration structure and free energies of metal ions in water in order to provide a comparison for the membrane channel… 

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