Hydrated Solid Forms of Theophylline and Caffeine Obtained by Mechanochemistry

  title={Hydrated Solid Forms of Theophylline and Caffeine Obtained by Mechanochemistry},
  author={Juan Saulo Gonz{\'a}lez-Gonz{\'a}lez and Oscar Z{\'u}{\~n}iga-Lemus and Mar{\'i}a Del and Carmen Hern{\'a}ndez-Galindo},
Caffeine and theophylline are methyl-xantine drugs, which are affected by water leading to their hydrated forms. The purpose of this work was to prepare and characterize hydrated forms of caffeine and theophylline by mechanochemistry. The obtained products were characterized by infrared spectroscopy and Xray powder diffraction. The infrared spectra and diffractograms of the ground products were similar to the reported for caffeine and theophylline hydrates. 

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  • K. Izutsu, T. Koide, N. Takata
  • Ikeda, M. Ono, M. Inoue, T. Fukami, E. Yonemochi…
  • 2016
1 Excerpt

Influence of Polymorphs on the Transformation Water Activity of Theophylline

  • C. Liu, L. Dang, Y. Tong, H. Wei
  • Industrial & Engineering Chemistry Research, 52
  • 2013
1 Excerpt


  • P. J. Barnes
  • American Journal of Respiratory and Critical Care…
  • 2013
1 Excerpt

The role of mechanochemistry and supramolecular design in the development of pharmaceutical materials

  • A. Delori, T. Friscic, W. Jones
  • CrystEngComm, 14
  • 2012
1 Excerpt


  • D. Komes, D. Horžić
  • Belščak , K.K. Ganič, A. Baljak, Determination of…
  • 2009
1 Excerpt

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