Hydrate Formation During Wet Granulation Studied by Spectroscopic Methods and Multivariate Analysis

@article{Jrgensen2002HydrateFD,
  title={Hydrate Formation During Wet Granulation Studied by Spectroscopic Methods and Multivariate Analysis},
  author={Anna Cecilia J\orgensen and Jukka Rantanen and Milja A Karjalainen and Leonid Khriachtchev and Eetu R{\"a}s{\"a}nen and Jouko K Yliruusi},
  journal={Pharmaceutical Research},
  year={2002},
  volume={19},
  pages={1285-1291}
}
Purpose. The aim was to follow hydrate formation of two structurally related drugs, theophylline and caffeine, during wet granulation using fast and nondestructive spectroscopic methods. Methods. Anhydrous theophylline and caffeine were granulated with purified water. Charge-coupled device (CCD) Raman spectroscopy was compared with near-infrared spectroscopy (NIR) in following hydrate formation of drugs during wet granulation (off-line). To perform an at-line process analysis, the effect of… CONTINUE READING

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