Hydramacin-1, Structure and Antibacterial Activity of a Protein from the Basal Metazoan Hydra*

@article{Jung2009Hydramacin1SA,
  title={Hydramacin-1, Structure and Antibacterial Activity of a Protein from the Basal Metazoan Hydra*},
  author={Sascha Jung and A. Dingley and R. Augustin and Friederike Anton-Erxleben and Mareike Stanisak and C. Gelhaus and T. Gutsmann and Malte U. Hammer and R. Podschun and A. Bonvin and M. Leippe and T. C. Bosch and J. Grötzinger},
  journal={Journal of Biological Chemistry},
  year={2009},
  volume={284},
  pages={1896 - 1905}
}
  • Sascha Jung, A. Dingley, +10 authors J. Grötzinger
  • Published 2009
  • Biology, Medicine
  • Journal of Biological Chemistry
  • Hydramacin-1 is a novel antimicrobial protein recently discovered during investigations of the epithelial defense of the ancient metazoan Hydra. The amino acid sequence of hydramacin-1 shows no sequence homology to any known antimicrobial proteins. Determination of the solution structure revealed that hydramacin-1 possesses a disulfide bridge-stabilized αβ motif. This motif is the common scaffold of the knottin protein fold. The structurally closest relatives are the scorpion oxin-like… CONTINUE READING
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