Hydramacin-1, Structure and Antibacterial Activity of a Protein from the Basal Metazoan Hydra*

@article{Jung2009Hydramacin1SA,
  title={Hydramacin-1, Structure and Antibacterial Activity of a Protein from the Basal Metazoan Hydra*},
  author={Sascha Jung and A. Dingley and R. Augustin and Friederike Anton-Erxleben and Mareike Stanisak and C. Gelhaus and T. Gutsmann and Malte U. Hammer and R. Podschun and A. Bonvin and M. Leippe and T. C. Bosch and J. Grötzinger},
  journal={Journal of Biological Chemistry},
  year={2009},
  volume={284},
  pages={1896 - 1905}
}
  • Sascha Jung, A. Dingley, +10 authors J. Grötzinger
  • Published 2009
  • Biology, Medicine
  • Journal of Biological Chemistry
    • Hydramacin-1 is a novel antimicrobial protein recently discovered during investigations of the epithelial defense of the ancient metazoan Hydra. The amino acid sequence of hydramacin-1 shows no sequence homology to any known antimicrobial proteins. Determination of the solution structure revealed that hydramacin-1 possesses a disulfide bridge-stabilized αβ motif. This motif is the common scaffold of the knottin protein fold. The structurally closest relatives are the scorpion oxin-like… CONTINUE READING
    View on ASBMB
    jbc.org
    106 Citations
    Highly Influencial Citations
    8
    Background Citations
    37
    Methods Citations
    4
    Results Citations
    1
    106 Citations
    Citation Type

    Citation Type

    Hydramacin-1 in Action: Scrutinizing the Barnacle Model
    • 8
    • PDF
    Activity of the Novel Peptide Arminin against Multiresistant Human Pathogens Shows the Considerable Potential of Phylogenetically Ancient Organisms as Drug Sources
    • 54
    • PDF
    Discovery of novel antimicrobial peptides: A transcriptomic study of the sea anemone Cnidopus japonicus
    • 6
    A novel cysteine-rich antimicrobial peptide from the mucus of the snail of Achatina fulica
    • 41
    Recombinant Production of Snakin-2 (an Antimicrobial Peptide from Tomato) in E. coli and Analysis of Its Bioactivity
    • 35
    • PDF
    Hornerin contains a Linked Series of Ribosome-Targeting Peptide Antibiotics
    • 9
    • PDF
    New Disulfide-Stabilized Fold Provides Sea Anemone Peptide to Exhibit Both Antimicrobial and TRPA1 Potentiating Properties
    • 27
    • PDF
    Solution structure and functional studies of the highly potent equine antimicrobial peptide DEFA1.
    • 1
    Defensin‐neurotoxin dyad in a basally branching metazoan sea anemone
    • 14
    STRUCTURAL, FUNCTIONAL AND EVOLUTIONARY STUDIES OF ANTIMICROBIAL PEPTIDES
    • 6
    • PDF

    References

    SHOWING 1-10 OF 34 REFERENCES
    Solution structures of the antifungal heliomicin and a selected variant with both antibacterial and antifungal activities.
    • 68
    The three-dimensional solution structure of NaD1, a new floral defensin from Nicotiana alata and its application to a homology model of the crop defense protein alfAFP.
    • 122
    Pore-forming Polypeptides of the Pathogenic Protozoon Naegleria fowleri *
    • 73
    • PDF
    Solution structure and activity of the synthetic four-disulfide bond Mediterranean mussel defensin (MGD-1).
    • 54
    Structure of Petunia hybrida defensin 1, a novel plant defensin with five disulfide bonds.
    • 89
    Molecular Characterization of Two Novel Antibacterial Peptides Inducible upon Bacterial Challenge in an Annelid, the Leech Theromyzon tessulatum*
    • 89
    • PDF
    Pore-forming peptide of pathogenic Entamoeba histolytica.
    • 172
    • PDF
    Molecular recognition between serine proteases and new bioactive microproteins with a knotted structure.
    • 98
    Refined crystal structure of the potato inhibitor complex of carboxypeptidase A at 2.5 A resolution.
    • 220
    Solution structure of two new toxins from the venom of the Chinese scorpion Buthus martensi Karsch blockers of potassium channels.
    • 30