Hydractinia, a pioneering model for stem cell biology and reprogramming somatic cells to pluripotency.

@article{Plickert2012HydractiniaAP,
  title={Hydractinia, a pioneering model for stem cell biology and reprogramming somatic cells to pluripotency.},
  author={G{\"u}nter Plickert and Uri Frank and Werner Alois M{\"u}ller},
  journal={The International journal of developmental biology},
  year={2012},
  volume={56 6-8},
  pages={519-34}
}
Hydractinia, a representative marine colonial hydroid, was the first organism in the history of biology in which migratory precursors of germ cells were described and termed "stem cells" (Weismann, 1883). These stem cells, now known as interstitial cells (i-cells), are thought to remain pluripotent throughout their life. Using animals depleted of their own stem cells and repopulated with allogeneic mutant donor stem cells, it was shown that Hydractinia i-cells differentiate into any cell type… CONTINUE READING
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