Hydra regeneration and epitheliopeptides

@article{Fujisawa2003HydraRA,
  title={Hydra regeneration and epitheliopeptides},
  author={Toshitaka Fujisawa},
  journal={Developmental Dynamics},
  year={2003},
  volume={226}
}
  • T. Fujisawa
  • Published 1 February 2003
  • Biology
  • Developmental Dynamics
Hydra has been well known for over 200 years for its remarkable regenerative capacity. In addition to small pieces excised from the body, reaggregates of dissociated single cells can also regenerate. Although the cellular events involved in the regeneration process have been well characterized, the underlying molecular mechanisms are yet to be uncovered. Recently, however, transcription factors and signaling molecules, both proteins and short peptides, have been identified and their role… 
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59 Citations
Background Citations
31
Methods Citations
4
Results Citations
1

59 Citations

Why polyps regenerate and we don't: towards a cellular and molecular framework for Hydra regeneration.

  • T. Bosch
  • Biology
    Developmental biology
  • 2007

Cell plasticity in homeostasis and regeneration

The freshwater Hydra polyp provides a unique model system to study the intricate relationships between the mechanisms that regulate the maintenance of homeostasis, even in extreme conditions and the reactivation of developmental programs after bisection or during budding.

Apoptotic cells provide an unexpected source of Wnt3 signaling to drive hydra head regeneration.

Generic and context-dependent gene modulations during Hydra whole body regeneration

A transcriptome-wide comparative analysis of apical and basal regeneration after decapitation and mid-gastric bisection is presented, augmented with a characterization of positional and cell-type expression patterns in non-regenerating animals.

Deer antlers: a zoological curiosity or the key to understanding organ regeneration in mammals?

Very little is known about the molecular machinery required for antler regeneration, although there is evidence that developmental signalling pathways with pleiotropic functions are important and that novel ‘antler‐specific’ molecules may not exist.

Head regeneration in wild-type hydra requires de novo neurogenesis

The function of the ParaHox gsx homolog gene, cnox-2, which is a specific marker for bipotent neuronal progenitors expressed in cycling interstitial cells that give rise to apical neurons and gastric nematoblasts, is tested in wild-type hydra and acts as an upstream regulator of the neuronal and nematocyte differentiation pathways.

REGENERATING THE BRA IN : LESSONS FROM THE RED SPOTTED

The red spotted newt is able to regenerate areas of the brain that are normally devoid of proliferating cells, and the neurotransmitter dopamine inhibits the proliferation of DA progenitor cells in a feedback-like manner, which could aid the development of techniques to evoke brain regeneration in humans.

Unraveling Tissue Regeneration Pathways Using Chemical Genetics*

Results indicate that signaling from exogenous glucocorticoids impairs blastema formation and limits regenerative capacity through an acute inflammation-independent mechanism, and demonstrate the feasibility of exploiting chemical genetics to define the pathways that govern vertebrate regeneration.

Hydra Peptide Project 1993–2007

  • T. Fujisawa
  • Biology
    Development, growth & differentiation
  • 2008
A systematic screening of peptide signaling molecules in Hydra magnipapillata (the Hydra Peptide Project) was launched in 1993 and at least the first phase of the project ended in 2007, and many novel neuropeptides were identified.

Subcellular localization of the epitheliopeptide, Hym-301, in hydra

The intracellular localization of Hym-301 in hydra is examined by using immunohistochemical and immunogold electron-microscopic analyses and it is found that the pattern of distribution of mature peptide is slightly different from that of its mRNA, and that it is stored in vesicles located adjacent to the cell membrane.
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References

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  • Biology, Chemistry
    BioEssays : news and reviews in molecular, cellular and developmental biology
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