Hydra regeneration and epitheliopeptides

@article{Fujisawa2003HydraRA,
  title={Hydra regeneration and epitheliopeptides},
  author={Toshitaka Fujisawa},
  journal={Developmental Dynamics},
  year={2003},
  volume={226}
}
  • T. Fujisawa
  • Published 1 February 2003
  • Biology, Medicine
  • Developmental Dynamics
Hydra has been well known for over 200 years for its remarkable regenerative capacity. In addition to small pieces excised from the body, reaggregates of dissociated single cells can also regenerate. Although the cellular events involved in the regeneration process have been well characterized, the underlying molecular mechanisms are yet to be uncovered. Recently, however, transcription factors and signaling molecules, both proteins and short peptides, have been identified and their role… Expand
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59 Citations
Background Citations
28
Methods Citations
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Results Citations
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59 Citations

Citation Type

Citation Type

Hydra, a niche for cell and developmental plasticity.
TLDR
Recent studies that identified genes involved in the immediate cytoprotective function played by gland cells after amputation; the early dedifferentiation of digestive cells into blastema-like cells during head regeneration, and the early late proliferation of neuronal progenitors required for head patterning are highlighted. Expand
Why polyps regenerate and we don't: towards a cellular and molecular framework for Hydra regeneration.
  • T. Bosch
  • Biology, Medicine
  • Developmental biology
  • 2007
TLDR
How the modular tissue architecture may allow continuous replacement of cells in Hydra is discussed and the discovery and regulation of factors controlling the transition from self-renewing epithelial stem cells to differentiated cells are described. Expand
Cell plasticity in homeostasis and regeneration
TLDR
The freshwater Hydra polyp provides a unique model system to study the intricate relationships between the mechanisms that regulate the maintenance of homeostasis, even in extreme conditions and the reactivation of developmental programs after bisection or during budding. Expand
Apoptotic cells provide an unexpected source of Wnt3 signaling to drive hydra head regeneration.
TLDR
It is proposed that different types of injuries induce distinct cellular modes of Hydra head regeneration, which nonetheless converge on a central effector, Wnt3, which is reminiscent of proliferative blastemas in regenerating limbs and of compensatory proliferation induced by dying cells in Drosophila imaginal discs. Expand
Generic and context-dependent gene modulations during Hydra whole body regeneration
TLDR
A transcriptome-wide comparative analysis of apical and basal regeneration after decapitation and mid-gastric bisection is presented, augmented with a characterization of positional and cell-type expression patterns in non-regenerating animals. Expand
Deer antlers: a zoological curiosity or the key to understanding organ regeneration in mammals?
TLDR
Very little is known about the molecular machinery required for antler regeneration, although there is evidence that developmental signalling pathways with pleiotropic functions are important and that novel ‘antler‐specific’ molecules may not exist. Expand
Head regeneration in wild-type hydra requires de novo neurogenesis
TLDR
The function of the ParaHox gsx homolog gene, cnox-2, which is a specific marker for bipotent neuronal progenitors expressed in cycling interstitial cells that give rise to apical neurons and gastric nematoblasts, is tested in wild-type hydra and acts as an upstream regulator of the neuronal and nematocyte differentiation pathways. Expand
REGENERATING THE BRA IN : LESSONS FROM THE RED SPOTTED
Unlike mammals, adult salamanders can regenerate their brain after injury in a process fuelled by neurogenesis. The aim of this thesis is to identify the cells that give rise to new neurons after… Expand
Unraveling Tissue Regeneration Pathways Using Chemical Genetics*
TLDR
Results indicate that signaling from exogenous glucocorticoids impairs blastema formation and limits regenerative capacity through an acute inflammation-independent mechanism, and demonstrate the feasibility of exploiting chemical genetics to define the pathways that govern vertebrate regeneration. Expand
Hydra Peptide Project 1993–2007
  • T. Fujisawa
  • Biology, Medicine
  • Development, growth & differentiation
  • 2008
TLDR
A systematic screening of peptide signaling molecules in Hydra magnipapillata (the Hydra Peptide Project) was launched in 1993 and at least the first phase of the project ended in 2007, and many novel neuropeptides were identified. Expand
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References

SHOWING 1-10 OF 63 REFERENCES
Epithelial cells in nerve-free hydra produce morphogenetic substances
TLDR
It is shown that epithelial cells in hydra have the potential to produce head activator and other morphogenetic factors, but that this property is repressed in the presence of nerves. Expand
Enhancement of foot formation in Hydra by a novel epitheliopeptide, Hym-323.
TLDR
Results suggest that Hym-323 is a peptide involved in a foot-patterning process in Hydra, and that the foot activation potential was increased in the peptide-treated tissue. Expand
Polyps, peptides and patterning
  • T. Bosch, T. Fujisawa
  • Biology, Medicine
  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2001
TLDR
The abundance of peptides in Hydra raises the question of whether, in early metazoan evolution, cell–cell communication was based mainly on these small molecules rather than on the growth‐factor‐like cytokines that control differentiation and development in higher animals. Expand
Genetic analysis of developmental mechanisms in hydra
Mutant hydra strains showing abnormal development can be isolated through sexual inbreeding of wild hydra. One such mutant strain, called reg-16, regenerates tentacles very poorly following… Expand
Development of Hydra lacking nerve and interstitial cells.
TLDR
It is concluded that hydra consisting only of epithelial cells are capable of essentially normal development and only in some quantitative aspects do I cell-free hydra develop abnormally. Expand
Epithelial morphogenesis in hydra requires de novo expression of extracellular matrix components and matrix metalloproteinases.
TLDR
The correlation of loss of the ECM, cell shape changes and subsequent de novo biogenesis of matrix and matrix-associated components were all functionally coupled by antisense experiments in which translation of HLM-beta1 and HMMP was blocked and head regeneration was reversibly inhibited. Expand
Genetic analysis of developmental mechanisms in hydra: III. Characterization of a regeneration deficient strain
TLDR
A chimaeric strain of hydra was produced by combining interstitial cells (and thus their differentiation products, nerve cells and nematocytes) of reg-16 hydra with epithelial cells of another strain which is capable of normal regeneration, suggesting that regeneration deficiency in reg- 16 is due to a defective polarity gradient. Expand
Isolation and characterization of two new morphogenetically active peptides from Hydra vulgaris.
TLDR
The data obtained by biological and radioimmunoassays show that the shorter peptide, pedin, is an excellent candidate for a major component of the 'foot-activating potential'. Expand
Hydra regeneration from recombined ectodermal and endodermal tissue. II. Differential stability in the ectodermal and endodermal epithelial organization.
TLDR
It is suggested that this dynamic nature of the hydra tissue, particularly the high plasticity of the endodermal epithelial sheet organization, may be an important element for the high regenerative capacity of this organism. Expand
Genetic analysis of developmental mechanisms in Hydra. II. Isolation and characterization of an interstitial cell-deficient strain.
TLDR
A mutant strain of Hydra magnipapillata was isolated that contained no interstitial cells, nerve cells or nematocytes and was very similar to the interstitial cell-deficient strain produced by Campbell (1976) by means of colchicine. Expand
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2
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4
5
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