Hydra as a tractable, long-lived model system for senescence

@inproceedings{Bellantuono2015HydraA,
  title={
Hydra as a tractable, long-lived model system for senescence},
  author={Anthony J. Bellantuono and Diane Bridge and Daniel E. Mart{\'i}nez},
  booktitle={Invertebrate reproduction & development},
  year={2015}
}
Hydra represents a unique model system for the study of senescence, with the opportunity for the comparison of non-aging and induced senescence. Hydra maintains three stem cell lineages, used for continuous tissue morphogenesis and replacement. Recent work has elucidated the roles of the insulin/IGF-1 signaling target FoxO, of Myc proteins, and of PIWI proteins in Hydra stem cells. Under laboratory culture conditions, Hydra vulgaris show no signs of aging even under long-term study. In contrast… CONTINUE READING