Hybridization properties of aromatic peptide nucleic acids: a novel class of oligonucleotide analogues.

Abstract

[structure: see text] The synthesis of APNA-PNA chimeras containing all four DNA bases will be described. The hybridization properties of APNA-PNA chimeras with DNA and RNA are consistent with plausible intramolecular interactions that could preorganize the oligomers in a duplex or triplex structure with complementary DNA or RNA. 

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