Hybridization and reaction-based fluorogenic nucleic acid probes.


We developed fluorogenic probes, which are photoactivated in the presence of specific nucleic acid templates with the release of fluorescent dyes. This templated reaction can be used to target specific nucleic acids in complex mixtures. We further demonstrate that this reaction can be monitored by single-molecule fluorescence imaging.

DOI: 10.1039/c2cc33827k


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@article{Dutta2012HybridizationAR, title={Hybridization and reaction-based fluorogenic nucleic acid probes.}, author={Subrata Dutta and Benjamin Flottmann and Mike Heilemann and Andriy Mokhir}, journal={Chemical communications}, year={2012}, volume={48 77}, pages={9664-6} }