Hybrid resistance in vitro. Possible role of both class I MHC and self peptides in determining the level of target cell sensitivity.


NK cells of F1 hybrids frequently exhibit an enhanced capacity to reject semisyngeneic parental bone marrow grafts, a phenomenon known as hybrid resistance. Attempts to define the mechanism whereby this occurs have been hampered by factors inherent in the use of an in vivo model, including the host immune response, microenvironment, immune cell trafficking… (More)


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