Hybrid polymeric micelles based on bioactive polypeptides as pH-responsive delivery systems against melanoma.

Abstract

The bioactive polymer poly(L-glutamic acid)n-b-poly(D, L-lactic acid)m was synthesized and used to form doxorubicin-loaded hybrid polymeric micelles to treat melanoma. These polymers exhibited pH-responsive changes in conformation, which controlled the diverse functionalities of the micelles. During circulation, poly(L-glutamic acid)n-b-poly(D, L-lactic… (More)
DOI: 10.1016/j.biomaterials.2014.04.117

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