Hybrid nanoparticle-based nicotine nanovaccines: Boosting the immunological efficacy by conjugation of potent carrier proteins.

@article{Zhao2018HybridNN,
  title={Hybrid nanoparticle-based nicotine nanovaccines: Boosting the immunological efficacy by conjugation of potent carrier proteins.},
  author={Zongmin Zhao and Yun Long Hu and Theresa M Harmon and Paul R. Pentel and Marion F Ehrich and Chenming Zhang},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  year={2018},
  volume={14 5},
  pages={
          1655-1665
        }
}
A series of hybrid nanoparticle-based nicotine nanovaccines (NanoNicVac) were engineered in this work by conjugating potent carrier protein candidates (Keyhole limpet hemocyanin (KLH) multimer, KLH subunit, cross-reactive material 197 (CRM197), or tetanus toxoid (TT)) for enhanced immunological efficacy. NanoNicVac with CRM197 or TT were processed by… CONTINUE READING