Hybrid nanocluster plasmonic resonator for immunological detection of hepatitis B virus.

@article{Draz2012HybridNP,
  title={Hybrid nanocluster plasmonic resonator for immunological detection of hepatitis B virus.},
  author={Mohamed Shehata Draz and Binbin Amanda Fang and Lanjuan Li and Zhi Rou Chen and Yingjie Wang and Yuhong Xu and Jun Yang and Kevin M. Killeen and F. Frank Chen},
  journal={ACS nano},
  year={2012},
  volume={6 9},
  pages={7634-43}
}
Approximately 88% of the world population lives in regions with intermediate to high incidence of Hepatitis B virus (HBV), yet current serological and DNA-based detection methods have limited sensitivity and convenience. Here, we describe a preassembled plasmonic resonance nanocluster for HBV detection. The gold nanoparticle acceptors (AuNPs), with HBV surface antigen (HBsAg) epitope, and quantum dot (QD) donors with Fab antibody, are assembled into an immuno-mediated 3D-oriented complex with… CONTINUE READING