Hybrid molecular probe for nucleic acid analysis in biological samples.

  title={Hybrid molecular probe for nucleic acid analysis in biological samples.},
  author={Chaoyong James Yang and Karen Martinez and Hui Lin and Weihong Tan},
  journal={Journal of the American Chemical Society},
  volume={128 31},
The ability to detect changes in gene expression, especially in real-time and with sensitivity sufficient enough to monitor small variations in a single-cell, will have considerable value in biomedical research and applications. Out of the many available molecular probes for intracellular monitoring of nucleic acids, molecular beacon (MB) is the most frequently used probe with the advantages of high sensitivity and selectivity. However, any processes in which the MB stem-loop structure is… CONTINUE READING
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