Hybrid model development for fed-batch bioprocesses ; combining physical equations with the metabolic network and black-box kinetics ∗

@inproceedings{Roubos1999HybridMD,
  title={Hybrid model development for fed-batch bioprocesses ; combining physical equations with the metabolic network and black-box kinetics ∗},
  author={Johannes A. Roubos and Preben Krabben and Magne Setnes and Robert Babuska and Joseph J. Heijnen and Henk B. Verbruggen},
  year={1999}
}
A hybrid modeling technique is proposed to make models during the development phase of a fed-batch bioprocess. A limited amount of data is available and experimental data are therefore combined with a priori information about the mass balances and the chemical reaction network inside the cell (the metabolic network). This information highly constraints the model, and only a few degrees of freedom remain in the static description. The dynamic part (kinetics) is described by fuzzy models or… CONTINUE READING

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