Hybrid liposomes inhibit growth and invasion of human osteosarcoma cells leading to apoptosis.

@article{Kitajima2012HybridLI,
  title={Hybrid liposomes inhibit growth and invasion of human osteosarcoma cells leading to apoptosis.},
  author={Hideki Kitajima and Yuji Komizu and Yoko Matsumoto},
  journal={Bioorganic & medicinal chemistry letters},
  year={2012},
  volume={22 4},
  pages={
          1784-7
        }
}
Marked inhibitory effects of hybrid liposomes (HL-n; n=21, 23, 25) composed of 90 mol% l-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(n) dodecyl ethers on the growth of two human osteosarcoma cell lines (MG-63 and U-2 OS) were obtained. Furthermore, fluorescence microscopic and flow cytometric analyses revealed the induction of apoptosis by HL-n in both cells. It is noteworthy that HL-23 could inhibit the invasion and migration of U-2 OS cells on the basis of matrigel… CONTINUE READING
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