Hybrid genomes of the polyomaviruses JC virus, BK virus, and simian virus 40: identification of sequences important for efficient transformation.

@article{Bollag1989HybridGO,
  title={Hybrid genomes of the polyomaviruses JC virus, BK virus, and simian virus 40: identification of sequences important for efficient transformation.},
  author={Brigitte Bollag and W F Chuke and Richard J. Frisque},
  journal={Journal of virology},
  year={1989},
  volume={63 2},
  pages={863-72}
}
Hybrid viral genomes were used to investigate the influence of specific polyomavirus sequences on the transforming behavior of JC virus (JCV). One set of chimeric DNAs was made by exchanging the regulatory regions between JCV and simian virus 40 (SV40) or JCV and BK virus (BKV). A second set of constructs was produced that expressed hybrid JCV-BKV T proteins under the control of either JCV or BKV regulatory signals. Transformation of Rat 2 cells with the parental and chimeric DNAs indicated… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 46 references

Character - ization of simian virus 40 large T antigen by using different monoclonal antibodies : Tp 53 complexes are preferentially ATPase active and adenylylated

M. J. Tevethia
J . Virol . • 1988

Construction and characterization of hybrid polyomavirus

Chuke, W.-F, D. L. Walker, L. B. Peitzman, R. J. Frisque
genomes. J. Virol • 1986

Construction and characterization of hybrid polyomavirus genomes

R. Clark, D. Nathans, R. Tjian
J . Virol . • 1986

Structure and function of SV 40 large - T antigen

R. Monier
Philos . Trans . R . Soc . Lond . B • 1986

The biology and molecular biology of JC virus , p . 327 - 377

N. P. Salzman
The Papovaviridae , the polyomaviruses • 1986

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