Hybrid cell vaccination resolves Leishmania donovani infection by eliciting a strong CD8+ cytotoxic T-lymphocyte response with concomitant suppression of interleukin-10 (IL-10) but not IL-4 or IL-13.

@article{Basu2007HybridCV,
  title={Hybrid cell vaccination resolves Leishmania donovani infection by eliciting a strong CD8+ cytotoxic T-lymphocyte response with concomitant suppression of interleukin-10 (IL-10) but not IL-4 or IL-13.},
  author={Rajatava Basu and Suniti Bhaumik and Arun Kumar Haldar and Kshudiram Naskar and Tripti De and Syamal Kumar Dana and Peter Walden and Syamal Roy},
  journal={Infection and immunity},
  year={2007},
  volume={75 12},
  pages={
          5956-66
        }
}
There is an acute dearth of therapeutic interventions against visceral leishmaniasis that is required to restore an established defective cell-mediated immune response. Hence, formulation of effective immunotherapy requires the use of dominant antigen(s) targeted to elicit a specific antiparasitic cellular immune response. We implemented hybrid cell vaccination therapy in Leishmania donovani-infected BALB/c mice by electrofusing dominant Leishmania antigen kinetoplastid membrane protein 11 (KMP… CONTINUE READING

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