Hybrid bombesin analogues: combining an agonist and an antagonist in defined distances for optimized tumor targeting.

@article{Kroll2013HybridBA,
  title={Hybrid bombesin analogues: combining an agonist and an antagonist in defined distances for optimized tumor targeting.},
  author={Carsten Kroll and Rosalba Mansi and Friederike Braun and Stefanie Dobitz and Helmut R. Maecke and Helma Wennemers},
  journal={Journal of the American Chemical Society},
  year={2013},
  volume={135 45},
  pages={16793-6}
}
Radiolabeled hybrid ligands with defined distances between an agonist and an antagonist for the gastrin-releasing peptide receptor were found to have excellent tumor-targeting properties. Oligoprolines served as rigid scaffolds that allowed for tailoring distances of 10, 20, and 30 Å between the recognition elements. In vitro and in vivo studies revealed… CONTINUE READING
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