Corpus ID: 34579852

Hybrid anticancer compounds. Steroidal lactam esters of carboxylic derivatives of N,N-bis (2-chloroethyl) aniline (review).

@article{Catsoulacos1991HybridAC,
  title={Hybrid anticancer compounds. Steroidal lactam esters of carboxylic derivatives of N,N-bis (2-chloroethyl) aniline (review).},
  author={P. Catsoulacos and D. Catsoulacos},
  journal={Anticancer research},
  year={1991},
  volume={11 5},
  pages={
          1773-7
        }
}
  • P. Catsoulacos, D. Catsoulacos
  • Published 1991
  • Chemistry, Medicine
  • Anticancer research
  • For the rational design of more specific alkylating agents, we suggested new biological platforms able to deliver the alkylating moieties to specific target site and on the other hand we hoped to lead in compounds with synergistic activity. As biological platforms have been used steroidal lactams of A and D- ring and as alkylating agents carboxylic derivatives of N,N-bis (2-Chloroethyl) aniline which combine to the steroid by an easily cleaved ester bond. These homo-aza-steroidal esters gave… CONTINUE READING
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