Hybrid anthracycline antibiotics: production of new anthracyclines by cloned genes from Streptomyces purpurascens in Streptomyces galilaeus.

@article{Niemi1994HybridAA,
  title={Hybrid anthracycline antibiotics: production of new anthracyclines by cloned genes from Streptomyces purpurascens in Streptomyces galilaeus.},
  author={Jarmo Niemi and Kristiina Ylihonko and Juha Hakala and R P{\"a}rssinen and Anja Kopio and Pekka M{\"a}nts{\"a}l{\"a}},
  journal={Microbiology},
  year={1994},
  volume={140 ( Pt 6)},
  pages={
          1351-8
        }
}
A DNA segment cloned from Streptomyces purpurascens ATCC 25489 close to a region that hybridized to a probe containing part of the actinorhodin polyketide synthase caused S. galilaeus ATCC 31615 to produce new anthracyclines. When transformed with certain sub-clones of this segment, the host produced glycosides of epsilon-rhodomycinone, beta-rhodomycinone, 10-demethoxycarbonylaklavinone and 11-deoxy-beta-rhodomycinone in addition to those of aklavinone, the natural anthracyclines of S… CONTINUE READING

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Hybrid antibiotics

  • Folia Microbiologica
  • 2003
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Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis

Sirke Torkkell, Kristiina Ylihonko, J. Hakala, Mikael Skurnik, Pekka Mäntsälä
  • Molecular and General Genetics MGG
  • 1997

A gene cluster involved in nogalamycin biosynthesis fromStreptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway

K. Ylihonko, J. Tuikkanen, S. Jussila, L. Cong, P. Mäntsälä
  • Molecular and General Genetics MGG
  • 1996
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