Hybrid Tetanus Toxin C Fragment-Diphtheria Toxin Translocation Domain Allows Specific Gene Transfer into PC12 Cells

@article{Barati2002HybridTT,
  title={Hybrid Tetanus Toxin C Fragment-Diphtheria Toxin Translocation Domain Allows Specific Gene Transfer into PC12 Cells},
  author={Shahram Barati and F Goodarzvand Chegini and P R Hurtado and Robert A. Rush},
  journal={Experimental Neurology},
  year={2002},
  volume={177},
  pages={75-87}
}
  • Shahram Barati, F Goodarzvand Chegini, +1 author Robert A. Rush
  • Published in Experimental Neurology 2002
  • Medicine, Biology
  • To study the mechanism by which genes can efficiently be transferred into specific cell types, we have constructed several novel, single-chain multicomponent proteins by recombining the nontoxic C fragment of tetanus toxin and the translocation domain of diphtheria toxin together with the DNA-binding fragment of GAL4 transcription factor, for transportation of plasmid DNA into neuronal cells. The C fragment of tetanus toxin provided neuronal selectivity, the translocation domain of diphtheria… CONTINUE READING

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