Hybrid SPECT/cardiac-gated first-pass perfusion CT: locating transplanted cells relative to infarcted myocardial targets.

@article{Sabondjian2012HybridSF,
  title={Hybrid SPECT/cardiac-gated first-pass perfusion CT: locating transplanted cells relative to infarcted myocardial targets.},
  author={Eric Sabondjian and Andrea J. Mitchell and Gerald Wisenberg and James White and Kimberley J. Blackwood and Jane Sykes and Lela Deans and Robert Z. Stodilka and Frank S. Prato},
  journal={Contrast media & molecular imaging},
  year={2012},
  volume={7 1},
  pages={76-84}
}
PURPOSE A challenge with cardiac cell therapy is determining the location of cells relative to infarct tissue. As cells are viable following ¹¹¹In-labeling, and first-pass CT imaging can identify regions of myocardial infarction, we evaluated the feasibility of a SPECT/CT system to localize cells relative to infarcted myocardium in a canine model. METHODS Ten canines underwent surgical ligation of the left-anterior-descending artery and endothelial progenitor cells labeled with ¹¹¹In… CONTINUE READING
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