Hybrid PET-optical imaging using targeted probes.

  title={Hybrid PET-optical imaging using targeted probes.},
  author={Matthias Nahrendorf and Edmund J. Keliher and Brett Marinelli and Peter Waterman and Paolo Fumene Feruglio and Lioubov Fexon and Misha Pivovarov and Filip K Swirski and Mikael J Pittet and Claudio Vinegoni and Ralph Weissleder},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 17},
Fusion imaging of radionuclide-based molecular (PET) and structural data [x-ray computed tomography (CT)] has been firmly established. Here we show that optical measurements [fluorescence-mediated tomography (FMT)] show exquisite congruence to radionuclide measurements and that information can be seamlessly integrated and visualized. Using biocompatible nanoparticles as a generic platform (containing a (18)F isotope and a far red fluorochrome), we show good correlations between FMT and PET in… CONTINUE READING


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