Hybrid PET/CT for noninvasive pharmacokinetic evaluation of dynamic PolyConjugates, a synthetic siRNA delivery system.

@article{Mudd2010HybridPF,
  title={Hybrid PET/CT for noninvasive pharmacokinetic evaluation of dynamic PolyConjugates, a synthetic siRNA delivery system.},
  author={Sarah R. Mudd and Vladimir S. Trubetskoy and Andrei V. Blokhin and Jamey P. Weichert and J. A. Wolff},
  journal={Bioconjugate chemistry},
  year={2010},
  volume={21 7},
  pages={1183-9}
}
Positron emission tomography/computed tomography (PET/CT) hybrid imaging can be used to gain insights into a synthetic siRNA delivery system targeted to the liver. Either siRNA or the delivery vehicle was labeled with (64)Cu via 1, 4, 7, 10- tetraazacyclododecane- 1, 4, 7, 10- tetraacetic acid (DOTA) chelation. This study confirmed that the siRNA delivery system was successfully targeted to the liver. Incorporation of the siRNA into the delivery system protected the siRNA from renal filtration… CONTINUE READING

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Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes.

Proceedings of the National Academy of Sciences of the United States of America • 2007

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