Hyaluronidases in cancer biology.

  title={Hyaluronidases in cancer biology.},
  author={Robert Stern},
  journal={Seminars in cancer biology},
  volume={18 4},
Hyaluronan is a megadalton glycosaminoglycan polymer critical for maintaining the integrity of the extracellular matrix. It can exist in a protein-bound state with aggregating proteoglycans, where it expands the extracellular matrix and modulates cell-cell interactions. It also exists in lower molecular weight forms that participate in a myriad of biological functions. It is unique in that much of it is degraded within hours of its synthesis. High molecular weight hyaluronan, a reflection of… CONTINUE READING
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