Hyaluronidases in cancer biology.

@article{Stern2008HyaluronidasesIC,
  title={Hyaluronidases in cancer biology.},
  author={Robert Stern},
  journal={Seminars in cancer biology},
  year={2008},
  volume={18 4},
  pages={275-80}
}
Hyaluronan is a megadalton glycosaminoglycan polymer critical for maintaining the integrity of the extracellular matrix. It can exist in a protein-bound state with aggregating proteoglycans, where it expands the extracellular matrix and modulates cell-cell interactions. It also exists in lower molecular weight forms that participate in a myriad of biological functions. It is unique in that much of it is degraded within hours of its synthesis. High molecular weight hyaluronan, a reflection of… CONTINUE READING
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Promoter methylation study of the H 37 / RBM 5 tumor suppressor gene from the 3 p 21 . 3 human lung cancer tumor suppressor locus

  • JJ Oh, BN Boctor, CA Jimenez, R Lopez, AK Koegel, EO Taschereau
  • Hum Genet
  • 2007

Concurrent expressionofhyaluronanbiosynthetic andprocessing enzymes promotes growth and vascularization of prostate tumors in mice

  • SimpsonMA
  • Am J Pathol
  • 2006

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