Hyaluronidase-induced periodic modulation of the interstitial fluid pressure increases selective antibody uptake in human osteosarcoma xenografts.

Abstract

Periodic modulation of the elevated interstitial fluid pressure might improve filtration and uptake of tumor-targeting macromolecules (e.g. radioimmunoconjugates) in solid tumors. Cycling of the tumor interstitial fluid pressure was initiated by intratumoral injections of bovine testicular hyaluronidase (BTH, 1,600 U) in osteosarcoma-bearing nude mice. BTH… (More)

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@article{Brekken2000HyaluronidaseinducedPM, title={Hyaluronidase-induced periodic modulation of the interstitial fluid pressure increases selective antibody uptake in human osteosarcoma xenografts.}, author={Christian Brekken and Mari H.B Hjelstuen and \O S Bruland and Catharina de Lange Davies}, journal={Anticancer research}, year={2000}, volume={20 5B}, pages={3513-9} }