Hyaluronidase 2 and its intriguing role as a cell-entry receptor for oncogenic sheep retroviruses.

@article{Miller2008Hyaluronidase2A,
  title={Hyaluronidase 2 and its intriguing role as a cell-entry receptor for oncogenic sheep retroviruses.},
  author={A Dusty Miller},
  journal={Seminars in cancer biology},
  year={2008},
  volume={18 4},
  pages={296-301}
}
Jaagsiekte sheep retrovirus (JSRV) causes lung adenocarcinoma in sheep and goats, while the closely related enzootic nasal tumor virus (ENTV) causes nasal tumors in the same species. The envelope (Env) protein from either virus can transform fibroblasts and epithelial cells in culture, indicating that the Env proteins are responsible for tumorigenesis. However, the primary function of retroviral Env proteins is to mediate virus entry into cells by interacting with specific cell-surface… CONTINUE READING
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