Hyaluronic acid promotes proliferation and migration of human meniscus cells via a CD44-dependent mechanism.

@article{Murakami2019HyaluronicAP,
  title={Hyaluronic acid promotes proliferation and migration of human meniscus cells via a CD44-dependent mechanism.},
  author={Tomohiko Murakami and Shuhei Otsuki and Yoshinori Okamoto and Kosuke Nakagawa and Hitoshi Wakama and Nobuhiro Okuno and Masashi Neo},
  journal={Connective tissue research},
  year={2019},
  volume={60 2},
  pages={
          117-127
        }
}
PURPOSE Treatment of meniscal injury is important for osteoarthritis (OA) prevention. Meniscus cells are divided between inner and outer cells, which have different characteristics and vascularity. We evaluated the effects of hyaluronic acid (HA) on the proliferation and migration of human inner and outer meniscus cells, and investigated the underlying healing mechanisms. MATERIALS AND METHODS Lateral menisci from 18 patients who underwent total knee arthroplasty were used. Meniscus cells… CONTINUE READING