Hyaluronic acid is an endogenous inducer of interleukin-1 production by human monocytes and rabbit macrophages.

@article{Hiro1986HyaluronicAI,
  title={Hyaluronic acid is an endogenous inducer of interleukin-1 production by human monocytes and rabbit macrophages.},
  author={D Hiro and Akira Ito and Kunio Matsuta and Yasuji Mori},
  journal={Biochemical and biophysical research communications},
  year={1986},
  volume={140 2},
  pages={715-22}
}
When human peripheral monocytes and rabbit peritoneal macrophages were incubated with hyaluronic acid, the media were found to contain interleukin-1 (IL-1) activity and to stimulate collagenase production by rabbit fibroblasts. A digestion of hyaluronic acid by testicular hyaluronidase decreased the IL-1 inducing activity. Polymixin B, an inhibitor of endotoxin, did not exert any effect towards the action of hyaluronic acid. Hyaluronic acid also stimulated human polymorphonuclear leucocytes to… CONTINUE READING