Hyaluronic acid inhibits nitric oxide-induced apoptosis and dedifferentiation of articular chondrocytes in vitro

@article{Peng2010HyaluronicAI,
  title={Hyaluronic acid inhibits nitric oxide-induced apoptosis and dedifferentiation of articular chondrocytes in vitro},
  author={Hao Peng and Jian-lin Zhou and Shi-qing Liu and Qiong-jie Hu and Jiang-hua Ming and Bo Qiu},
  journal={Inflammation Research},
  year={2010},
  volume={59},
  pages={519-530}
}
Nitric oxide is an important mediator in Osteoarthritis (OA), and causes apoptosis and dedifferentiation in articular chondrocytes. Protein kinase Cα is involved in modulating apoptosis and dedifferentiation of articular chondrocytes induced by nitric oxide. Hyaluronic acid is widely used in the treatment of osteoarthritis and exerts significant chondroprotective effects. The exact mechanisms of its chondroprotective action are not yet fully elucidated. The present study was performed to… CONTINUE READING
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