Hyaluronic acid inhibits mRNA expression of proinflammatory cytokines and cyclooxygenase-2/prostaglandin E(2) production via CD44 in interleukin-1-stimulated subacromial synovial fibroblasts from patients with rotator cuff disease.

@article{Mitsui2008HyaluronicAI,
  title={Hyaluronic acid inhibits mRNA expression of proinflammatory cytokines and cyclooxygenase-2/prostaglandin E(2) production via CD44 in interleukin-1-stimulated subacromial synovial fibroblasts from patients with rotator cuff disease.},
  author={Yasuhiro Mitsui and Masafumi Gotoh and Kenjirou Nakama and Tetsu Yamada and Fujio Higuchi and Kensei Nagata},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2008},
  volume={26 7},
  pages={1032-7}
}
A growing body of evidence supports use of intraarticular hyaluronic acid (HA) injection in patients with rotator cuff disease. However, the mechanism of its anti-inflammatory action has not been clarified. We examined the effects of HA on the expression of mRNAs for proinflammatory cytokines (IL-1beta, IL-6, and TNF-alpha and COX-2/PGE(2) production in IL-1-stimulated subacromial-synovium fibroblasts (SSF) derived from patients with rotator cuff disease. Various concentrations of HA were added… CONTINUE READING

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