Hyaluronic acid inhibits adhesion of hepatic stellate cells in spite of its stimulation of DNA synthesis.

@article{Cho2004HyaluronicAI,
  title={Hyaluronic acid inhibits adhesion of hepatic stellate cells in spite of its stimulation of DNA synthesis.},
  author={Min K. Cho and Gum Hwa Lee and Eun Young Park and Sang Geon Kim},
  journal={Tissue & cell},
  year={2004},
  volume={36 5},
  pages={293-305}
}
Unbalanced accumulation of fibers in extracellular matrix (ECM) results from attachment and activation of hepatic stellate cells (HSCs) during chronic liver diseases, in which the content of hyaluronic acid (HA), a glycosaminoglycan, in ECM changes. No information is available on the effect of HA on adhesion and activation of HSCs although that of collagen (Col) on HSCs was extensively studied. This study investigated the effects of HA with or without Col on adhesion of HSCs or the rate of DNA… CONTINUE READING

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