Hyaluronic acid family in bladder cancer: potential prognostic biomarkers and therapeutic targets

@article{Morera2017HyaluronicAF,
  title={Hyaluronic acid family in bladder cancer: potential prognostic biomarkers and therapeutic targets},
  author={Daley S. Morera and Martin S Hennig and Asif M Talukder and Soum D. Lokeshwar and Jiaojiao Wang and Michael L. Garcia-Roig and Nicolas Ortiz and Travis J. Yates and Luis E. Lopez and Georgios Kallifatidis and Mario Wolfgang Kramer and Andre R. Jordan and Axel S Merseburger and Murugesan Manoharan and Mark S. Soloway and Martha K. Terris and Vinata B. Lokeshwar},
  journal={British Journal of Cancer},
  year={2017},
  volume={117},
  pages={1507 - 1517}
}
Background:Molecular markers of clinical outcome may aid in designing targeted treatments for bladder cancer. However, only a few bladder cancer biomarkers have been examined as therapeutic targets.Methods:Data from The Cancer Genome Atlas (TCGA) and bladder specimens were evaluated to determine the biomarker potential of the hyaluronic acid (HA) family of molecules – HA synthases, HA receptors and hyaluronidase. The therapeutic efficacy of 4-methylumbelliferone (4MU), a HA synthesis inhibitor… Expand
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