Hyaluronic acid derivative-coated nanohybrid liposomes for cancer imaging and drug delivery.

@article{Park2014HyaluronicAD,
  title={Hyaluronic acid derivative-coated nanohybrid liposomes for cancer imaging and drug delivery.},
  author={Ju-Hwan Park and Hyun-Jong Cho and Hong Yeol Yoon and In-Soo Yoon and Seung-Hak Ko and Jae-Seong Shim and J Cho and Jae Hyung Park and Kwangmeyung Kim and Ick Chan Kwon and Dae-Duk Kim},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2014},
  volume={174},
  pages={98-108}
}
Nanohybrid liposomes coated with amphiphilic hyaluronic acid-ceramide (HACE) was fabricated for targeted delivery of anticancer drug and in vivo cancer imaging. Nanohybrid liposomes including doxorubicin (DOX) and Magnevist, a contrast agent for magnetic resonance (MR) imaging, with 120-130nm mean diameter and a narrow size distribution were developed. DOX release from the developed formulation was improved at acidic pH (pH5.5 and 6.8) versus physiological pH (pH7.4). Cytotoxicity induced by… CONTINUE READING

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