Hyaluronic acid-coated niosomes facilitate tacrolimus ocular delivery: Mucoadhesion, precorneal retention, aqueous humor pharmacokinetics, and transcorneal permeability.

Abstract

Tacrolimus (FK506) was used to prevent corneal allograft rejection in patients who were resistant to steroids and cyclosporine. However, the formulation for FK506 ocular delivery remained a challenge due to the drug's high hydrophobicity, high molecular weight, and eye's physiological and anatomical constraints. The aim of this project is to develop an… (More)
DOI: 10.1016/j.colsurfb.2016.01.014

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Cite this paper

@article{Zeng2016HyaluronicAN, title={Hyaluronic acid-coated niosomes facilitate tacrolimus ocular delivery: Mucoadhesion, precorneal retention, aqueous humor pharmacokinetics, and transcorneal permeability.}, author={Weidong Zeng and Qi Li and Tao Wan and Cui Liu and Wenhui Pan and Zushuai Wu and Guoguang Zhang and Jingtong Pan and Mengyao Qin and Yuanyuan Lin and Chuanbin Wu and Y. H. Xu}, journal={Colloids and surfaces. B, Biointerfaces}, year={2016}, volume={141}, pages={28-35} }