Hyaluronic acid-coated nanostructured lipid carriers for targeting paclitaxel to cancer.

@article{Yang2013HyaluronicAN,
  title={Hyaluronic acid-coated nanostructured lipid carriers for targeting paclitaxel to cancer.},
  author={Xiaoyan Yang and Yun-xia Li and Min Li and Li Zhang and Li-Xia Feng and Na Zhang},
  journal={Cancer letters},
  year={2013},
  volume={334 2},
  pages={338-45}
}
The aim of our study was to develop hyaluronic acid-coated, paclitaxel-loaded, nanostructured lipid carriers (HA-NLCs) prepared via electrostatic attraction for delivering paclitaxel (PTX) to tumors overexpressing CD44. First, cationic PTX-NLC was prepared by melt emulsion technology. Then, PTX-NLC were coated with hyaluronic acid (HA). The in vitro release of PTX was evaluated by the dialysis method. This analysis showed that PTX was released more slowly from HA-NLC than from Taxol®. The in… CONTINUE READING
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