Hyaluronic acid accumulation and redistribution in rejecting rat kidney graft. Relationship to the transplantation edema

@article{Hllgren1990HyaluronicAA,
  title={Hyaluronic acid accumulation and redistribution in rejecting rat kidney graft. Relationship to the transplantation edema},
  author={Roger H{\"a}llgren and Bengt Gerdin and Gunnar Tufveson},
  journal={The Journal of Experimental Medicine},
  year={1990},
  volume={171},
  pages={2063 - 2076}
}
By using biotin-labeled proteoglycan core protein and an avidin-enzyme system, hyaluronic acid (HA) was visualized in rat kidney. In the normal kidney, HA was localized in the extracellular space of the inner medulla and increased markedly towards the papillary tip. No staining for HA was seen in the interstitial tissue of the cortex or the outer medulla. During the development of rejection of allogeneic renal grafts, a progressive increase in accumulated HA was seen in the interstitial tissue… CONTINUE READING
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