Hyaluronic acid-N-hydroxysuccinimide: a useful intermediate for bioconjugation.

  title={Hyaluronic acid-N-hydroxysuccinimide: a useful intermediate for bioconjugation.},
  author={Yi Luo and Glenn D. Prestwich},
  journal={Bioconjugate chemistry},
  volume={12 6},
Hyaluronic acid (HA) is an abundant nonsulfated glycosaminoglycan component of synovial fluid and the extracellular matrix. HA is an important building block for biocompatible and biointeractive materials with applications in drug delivery, tissue engineering, wound repair, and viscosupplementation. Herein we describe the synthesis and characterization of HA-N-succinimide, an activated ester of the glucuronic acid moiety. This HA-active ester intermediate is a precursor for fluorescent probes… CONTINUE READING


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