Hyaluronic acid, HAS1, and HAS2 are significantly upregulated during muscle hypertrophy.

@article{Calve2012HyaluronicAH,
  title={Hyaluronic acid, HAS1, and HAS2 are significantly upregulated during muscle hypertrophy.},
  author={Sarah Calve and Jahdonna Isaac and Jonathan P. Gumucio and Christopher L Mendias},
  journal={American journal of physiology. Cell physiology},
  year={2012},
  volume={303 5},
  pages={C577-88}
}
Hyaluronic acid (HA) is a component of the extracellular matrix (ECM) in most vertebrate tissues and is thought to play a significant role during development, wound healing, and regeneration. In vitro studies have shown that HA enhances muscle progenitor cell recruitment and inhibits premature myotube fusion, implicating a role for this glycosaminoglycan in functional repair. However, the spatiotemporal distribution of HA during muscle growth and repair was unknown. We hypothesized that… CONTINUE READING

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