Hyaluronectin blocks the stimulatory effect of hyaluronan-derived fragments on endothelial cells during angiogenesis in vitro.

@article{Trochon1997HyaluronectinBT,
  title={Hyaluronectin blocks the stimulatory effect of hyaluronan-derived fragments on endothelial cells during angiogenesis in vitro.},
  author={V{\'e}ronique Trochon and C Mabilat-Pragnon and Philippe Bertrand and Yves J. Legrand and Jeannette Soria and C. I. M. A. Arturo Soria and Bertrand Delpech and He Min Lu},
  journal={FEBS letters},
  year={1997},
  volume={418 1-2},
  pages={6-10}
}
Hyaluronic acid (HA) is a glycosaminoglycan of the extracellular matrix. Its fragmentation by the hyaluronidase, secreted by tumor cells, facilitates tumor invasion and the HA degradation products generated stimulate angiogenesis. We report here that the HA-binding protein hyaluronectin (HN) inhibits the stimulatory effect of HA-derived fragments on the proliferation and migration of endothelial cells in vitro, and hampers the organization of endothelial cells into capillary-like structures… CONTINUE READING

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Hyaluronectin blocks the stimulatory effect of hyaluronan - derived fragments on endothelial cells during angiogenesis in vitro . Hyaluronic acid ( HA ) is a glycosaminoglycan of the extracellular matrix .
Hyaluronectin blocks the stimulatory effect of hyaluronan - derived fragments on endothelial cells during angiogenesis in vitro . Hyaluronic acid ( HA ) is a glycosaminoglycan of the extracellular matrix .
Hyaluronectin blocks the stimulatory effect of hyaluronan - derived fragments on endothelial cells during angiogenesis in vitro . Hyaluronic acid ( HA ) is a glycosaminoglycan of the extracellular matrix .
Hyaluronectin blocks the stimulatory effect of hyaluronan - derived fragments on endothelial cells during angiogenesis in vitro . Hyaluronic acid ( HA ) is a glycosaminoglycan of the extracellular matrix .
Hyaluronectin blocks the stimulatory effect of hyaluronan - derived fragments on endothelial cells during angiogenesis in vitro . Hyaluronic acid ( HA ) is a glycosaminoglycan of the extracellular matrix .
Hyaluronectin blocks the stimulatory effect of hyaluronan - derived fragments on endothelial cells during angiogenesis in vitro . Hyaluronic acid ( HA ) is a glycosaminoglycan of the extracellular matrix .
Hyaluronectin blocks the stimulatory effect of hyaluronan - derived fragments on endothelial cells during angiogenesis in vitro . Hyaluronic acid ( HA ) is a glycosaminoglycan of the extracellular matrix .
Hyaluronectin blocks the stimulatory effect of hyaluronan - derived fragments on endothelial cells during angiogenesis in vitro . Hyaluronic acid ( HA ) is a glycosaminoglycan of the extracellular matrix .
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