Hyaluronate in morphogenesis: inhibition of chondrogenesis in vitro.

@article{Toole1972HyaluronateIM,
  title={Hyaluronate in morphogenesis: inhibition of chondrogenesis in vitro.},
  author={Bryan P. Toole and George Jackson and Jerome Gross},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1972},
  volume={69 6},
  pages={1384-6}
}
Purified hyaluronate, at a concentration as low as 1 ng/ml, blocks the formation of colonies and cartilage nodules in stationary cultures of cells, isolated by treatment with trypsin, from embryonic chick somites and limb buds. This phenomenon in vitro is correlated with sequences of hyaluronate production and hyaluronidase activity during chondrogenesis in… CONTINUE READING