Hyaluronate-gold nanoparticle/tocilizumab complex for the treatment of rheumatoid arthritis.

@article{Lee2014HyaluronategoldNC,
  title={Hyaluronate-gold nanoparticle/tocilizumab complex for the treatment of rheumatoid arthritis.},
  author={Hwiwon Lee and M Lee and Suk Ho Bhang and Byung-Soo Kim and Yun Seop Kim and Ji Hyeon Ju and Ki Su Kim and Sei Kwang Hahn},
  journal={ACS nano},
  year={2014},
  volume={8 5},
  pages={4790-8}
}
Rheumatoid arthritis (RA) is a chronic inflammatory immune disease causing the inflammation of synovial membrane and the articular cartilage destruction. In this work, hyaluronate-gold nanoparticle/Tocilizumab (HA-AuNP/TCZ) complex was prepared for the treatment of RA. AuNP was used as a drug carrier with antiangiogenic effect. TCZ is a humanized monoclonal antibody against the interleukin-6 (IL-6) receptor and used as an immunosuppressive drug by interfering IL-6 in the pathogenesis of RA. HA… CONTINUE READING

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