Hyaluronan synthase 3 regulates hyaluronan synthesis in cultured human keratinocytes.

@article{Sayo2002HyaluronanS3,
  title={Hyaluronan synthase 3 regulates hyaluronan synthesis in cultured human keratinocytes.},
  author={Tetsuya Sayo and Yoshinori Sugiyama and Yoshito Takahashi and Naoko Ozawa and Shingo Sakai and Osamu Ishikawa and Masaaki Tamura and Shintaro Inoue},
  journal={The Journal of investigative dermatology},
  year={2002},
  volume={118 1},
  pages={43-8}
}
Three human hyaluronan synthase genes (HAS1, HAS2, and HAS3) have been cloned, but the functional differences between these HAS genes remains obscure. The purpose of this study was to examine which of the HAS genes are selectively regulated in epidermis. We examined the relation of changes between hyaluronan production and HAS gene expression when cytokines were added to cultured human keratinocytes. Interferon-gamma increased hyaluronan production whereas transforming growth factor beta… CONTINUE READING