Hyaluronan serum concentrations are elevated in critically ill patients and associated with disease severity.

@article{Yagmur2012HyaluronanSC,
  title={Hyaluronan serum concentrations are elevated in critically ill patients and associated with disease severity.},
  author={Eray Yagmur and Alexander Koch and Michaela Haumann and Rafael Kramann and Christian Trautwein and Frank Tacke},
  journal={Clinical biochemistry},
  year={2012},
  volume={45 1-2},
  pages={82-7}
}
OBJECTIVES The matrix protein hyaluronic acid (HA, hyaluronan) has possibly additional immune-regulatory functions in inflammation. We aimed at evaluating serum HA concentrations in critically ill patients. DESIGN AND METHODS We analyzed serum HA levels in 164 critically ill patients at a medical ICU and 61 healthy controls, with respect to organ dysfunction, systemic inflammation and mortality. RESULTS Hyaluronan serum concentrations upon admission to ICU were significantly elevated in… CONTINUE READING