Hyaluronan regulation of vascular integrity.

  title={Hyaluronan regulation of vascular integrity.},
  author={Frances E. Lennon and Patrick A. Singleton},
  journal={American journal of cardiovascular disease},
  volume={1 3},
Vascular integrity or the maintenance of blood vessel continuity is a fundamental process regulated, in part, by the endothelial glycocalyx and cell-cell junctions. Defects in endothelial barrier function are an initiating factor in several disease processes including atherosclerosis, ischemia/reperfusion, tumor angiogenesis, cancer metastasis, diabetes, sepsis and acute lung injury. The glycosaminoglycan, hyaluronan (HA), maintains vascular integrity through endothelial glycocalyx modulation… CONTINUE READING


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