Hyaluronan preserves the proliferation and differentiation potentials of long-term cultured murine adipose-derived stromal cells.

Abstract

For long-term culture, murine adipose-derived stromal cells (mADSCs) at latter passages demonstrated a marked decline in proliferative activity, exhibited senescent morphology and reduced differentiation potentials, particularly osteogenesis. To extend the lifespan of mADSCs, two culture conditions containing hyaluronan (HA) was compared in our study, one… (More)

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