Hyaluronan on the surface of tumor cells is correlated with metastatic behavior.

@article{Zhang1995HyaluronanOT,
  title={Hyaluronan on the surface of tumor cells is correlated with metastatic behavior.},
  author={Luoping Zhang and Charles B. Underhill and Lieping Chen},
  journal={Cancer research},
  year={1995},
  volume={55 2},
  pages={428-33}
}
In the present study, we examined the metastatic potential of tumor cells expressing different levels of cell surface hyaluronan. We used flow cytometry to isolate subsets of the B16-F1 mouse melanoma cell line that expressed either high (HA-H) or low (HA-L) amounts of hyaluronan on their surfaces. These two subsets of cells showed a 32-fold difference in the amount of cell surface hyaluronan, due to its rate of synthesis. However, these cell lines did not differ from each other with regard to… CONTINUE READING
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