Hyaluronan-mediated angiogenesis in vascular disease: uncovering RHAMM and CD44 receptor signaling pathways.

@article{Slevin2007HyaluronanmediatedAI,
  title={Hyaluronan-mediated angiogenesis in vascular disease: uncovering RHAMM and CD44 receptor signaling pathways.},
  author={Mark Slevin and Jurek Krupinski and John Gaffney and Sabine Matou and David West and Horace Delisser and Rashmin C. Savani and Shant Kumar},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  year={2007},
  volume={26 1},
  pages={
          58-68
        }
}
The correct formation of new blood vessels from existing vasculature (angiogenesis) is essential for embryogenesis and the effective repair of damaged or wounded tissues. However, excessive and detrimental vascularization also occurs in neoplasia, promoting tumour growth and metastasis, as well as in proliferative diabetic retinopathy and atherosclerosis. Greater understanding of the mechanisms controlling the angiogenic process will allow optimization of wound healing, and provide mechanisms… CONTINUE READING
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