Hyaluronan keeps mesenchymal stem cells quiescent and maintains the differentiation potential over time

@article{Wong2017HyaluronanKM,
  title={Hyaluronan keeps mesenchymal stem cells quiescent and maintains the differentiation potential over time},
  author={Tzyy Yue Wong and Chiung‐Hsin Chang and Chen-Hsiang Yu and Lynn L. H. Huang},
  journal={Aging Cell},
  year={2017},
  volume={16},
  pages={451 - 460}
}
  • Tzyy Yue Wong, Chiung‐Hsin Chang, +1 author Lynn L. H. Huang
  • Published 2017
  • Biology, Medicine
  • Aging Cell
  • Hyaluronan (HA), an abundant polysaccharide found in human bodies, plays a role in the mesenchymal stem cells (MSCs) maintenance. We had previously found that HA prolonged the lifespan, and prevented the cellular aging of murine adipose‐derived stromal cells. Recently, we had also summarized the potential pathways associated with HA regulation in human MSCs. In this study, we used the human placenta‐derived MSCs (PDMSC) to investigate the effectiveness of HA in maintaining the PDMSC. We found… CONTINUE READING
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